Insect repellents



Patented Jan. 9, 1951 2,537,023

UNITED STATES PATENT OFFICE INSECT REPELLENTS Paul D. Bartlett, Weston,Mass, and Abraham Schneider, Philadelphia, Pa., assignors to the UnitedStates of America as represented by the Secretary of the Army NoDrawing. Application January 7, 1949, Serial No. 69,836

7 Claims. (Cl. 167-30) 1 2 This invention relates to insect repellents.2 on, We have found that the application of cer- ECOOCCH tainunsubstituted or substituted indanols to the human skin or to the fabricaffords effective protection against insect bites by repelling in- 6 OHsects, particularly Aedes aegypti and Anopheles 3 quadrimaculatus. g E

A number of tests to measure the repellency of these compounds againstAedes aegypti and CH1 Anopheles quadrimaculatus was conducted by 4 0H,smearing the compound on the arms of test per- 6 E 0H sonnel, who thenthrust their arms into cages g containing Aedes aegypti. The arms wereex- A posed for 30-minute intervals at 3 minutes each CH: until thefirst insect bite. For ease of application the substituted or un- Teststo measure the repellency against Aedes substituted indanolscontemplated by the presaegypti of fabrics impregnated with these comentinvention may be incorporated in a suitable pounds were conducted byuniformly impregnatinert liquid or solid carrier such as mineral oil,ing mercerized cotton hose with the compound alcohol, petrolatum, etc.For facile and uniat a rate equivalent to 3.3 gms. per sq. ft., drawformfabric impregnation, they may be applied ing the dried hose over thearms of test perin an inert solvent, such as alcohol, ether, etc.sonnel, who then thrust their covered arms into Having thus describedour invention, we cages containing Aedes aegy'pti for 1 to 2 minclaim:utes. If no bites or less than 5 bites were re- -1. An insect repellentfabric impregnated with ceived, the tests .were repeated each successivea substance being a member of the group 'conday until 5 or more bitesduring one exposure sisting of indanol, acetoxy indanol, and methoxywere received. indanol. 4

Among the indanols possessing insect repel- 2. An insect repellentfabric impregnated lent properties are alpha-indanol, beta-indanol, withindanol. and their methoxy and acetoxy substituents. 3. An insectrepellent fabric impregnated The following table illustrates the insectrewith beta indanol. pellency conferred by four typical compounds 4. Aninsect repellent fabric impregnated contemplated by our invention: with2-acetoxy-alpha-indanol.

5. An insect repellent fabric impregnated with methoxy indanol.

Repellency on Appli- 6. An insect repellent fabric impregnated skinRepellepoy of with l-methoxy-beta-indanol.

55 22 232; 7. A composition for imparting insect repel- Agdu 5%? A lencyto a region from which the insects are to maculatua be repelled, saidcomposition comprising methoxy-beta-indanol in an inert non-gaseous or-Alpha-lndanol 1 tofidays. Eanic applicator. i'fififfiiaflti i at 16 15days. PAUL n. BARTLETT. l-methoxy-beta-indanol- 232 min. 45111111...-over when. 5 ABRAHAM SCHNEIDER.

REFERENCES CITED 1 on, The following references are of record in the mmfile of this patent:

Beilstein: Handbuch d. Org. Che.," 4th ed.. 1 vol. 8, pages 574, 575;vol. 6, first supplement,

3 page 288; vol. 6, page 970.

1. AN INSECT REPELLENT FABRIC IMPREGNATED WITH A SUBSTANCE BEING AMEMBER OF THE GROUP CONSISTING OF INDANOL, ACETOXY INDANOL, AND METHOXYINDANOL.